(WASHINGTON) -- The U.S. military coordinated closely with the Israeli Defense Forces to help defend against Tuesday's Iranian missile attack, national security adviser Jake Sullivan told reporters at a White House briefing shortly after the strike appeared to have ended.
"U.S. naval destroyers joined Israeli Air Defense units in firing interceptors to shoot down inbound missiles," he said.
At the Pentagon, Maj. Gen. Pat Ryder told reporters that two U.S. Navy destroyers fired "approximately a dozen" missile interceptors at the incoming ballistic missile barrage aimed at Israel.
Ryder said the two destroyers that launched missile interceptors were the USS Bulkeley and USS Cole that were in the eastern Mediterranean on the ongoing missile defense mission.
"We do not know of any damage to aircraft or strategic military assets in Israel. In short, based on what we know at this point, this attack appears to have been defeated and ineffective," Sullivan said.
At the same time, he called it a "significant escalation" by Iran.
President Joe Biden and Vice President Kamala Harris monitored the Iranian attack against Israel from the White House Situation Room and received regular updates from their national security team, Sullivan said.
The president had directed the U.S. military to aid Israel's defense against Iranian attacks and to help shoot down missiles targeting Israel.
Earlier, before the strike began, Biden had posted on X that the U.S. was ready to help Israel defend against the Iranian missile attack.
He said as well that the U.S. was ready to protect American personnel in the region.
Asked at the briefing whether Biden would recommend Israel have a limited response as he did after Iran's attack in Israel in April, Sullivan declined to say.
"I will not, from this podium, share the president's recommendations. He will have the opportunity to share them directly. We're going to have, as I said, ongoing consultations with the Israelis this afternoon and this evening. It is too early for me to tell you anything publicly in terms of our assessment or in terms of what our expectations are of the Israelis or the advice that we will give them," he said.
Before the strike began, the Pentagon said Secretary of Defense Lloyd J. Austin spoke with Israeli Minister of Defense Yoav Gallant to discuss the threat of an imminent Iranian attack against Israel.
A spokesman said they spoke about severe consequences "in the event Iran chooses to launch a direct military attack against Israel."
One of the first reactions from a congressional lawmaker came from from South Carolina GOP Sen. Lindsey Graham who called Iran's missile attack on Israel a "breaking point" and called for a response.
"I would urge the Biden Administration to coordinate an overwhelming response with Israel, starting with Iran's ability to refine oil," Graham said in a statement.
He called for oil refineries to be "hit and hit hard."
President Biden had been scheduled to hold a call with rabbis ahead of the Jewish High Holidays but the White House said that call has now postponed.
House Speaker Mike Johnson was briefed on the Iranian strikes on Israel, according to his spokesperson.
"Pray for Israel," Johnston said in a statement posted on X.
ABC News' Luis Martinez and Lauren Peller contributed to this report.